Skip to main content

Table 2 Breast cancer risk factors and antibiotic use in patients recruited at the Cleveland Clinic

From: Human breast microbiome correlates with prognostic features and immunological signatures in breast cancer

Variable

Cancer

(n = 48)

High-risk

(n = 7)

Healthy control

(n = 11)

p-value

Age at menarche (years)

13 (12–13)

12 (12–13)

11 (10–12)

0.230

Postmenopausal

28 (58%)

5 (71%)

4 (36%)

0.367

Gravity/parity

2 (1–3.8)/2 (1–3)

2 (1–3)/2 (0–3)

1.5 (0–2.5)/1 (0–2.3)

0.309/0.397

OCP or HRT usea

33 (69%)

6 (100%)

4 (57%)

0.248

Family history of breast cancera

26 (54%)

4 (67%)

0 (0%)

0.001

Alcohol usea

   

0.421

 Frequent

19 (40%)

2 (28.5%)

4 (40%)

 

 Occasional

12 (25%)

2 (28.5%)

5 (50%)

 

 None

17 (35%)

3 (43%)

1 (10%)

 

Last oral antibiotic usea

   

0.985

 < 1 month ago

6 (17%)

1 (17%)

2 (20%)

 

 1–6 months ago

12 (34%)

2 (33%)

4 (40%)

 

 > 6 months ago

17 (49%)

3 (50%)

4 (40%)

 
  1. Data are presented as number of patients (%) or median (interquartile range)
  2. aMissing data: OCP or HRT use (n = 5), family history (n = 1), alcohol use (n = 1), and antibiotic use (n = 15). Percentages are calculated from the total number of patients with known values
  3. OCP, oral contraceptive pill; HRT, hormone replacement therapy