Fig. 1

Overview of trans-ethnic and ethnic-specific CpGs associated with kidney function. a Venn diagram showing trans-ethnic and unique CpGs across the top 1000 sites for European Americans (EA), African Americans (AA), Hispanic/Latino (H/L), and trans-ethnic groups. b Euler diagram showing the number of overlapping CpGs (1) between trans-ethnic replicated DMPs (13) and discovery ethnic-specific DMPs for African Americans -AA- (5). c Study design, consortium information, sample size, and the number of significant DMPs for both trans-ethnic and ethnic-specific EWAS analyses. Details shown both for discovery (top) and replication analyses (bottom). For these analyses, consortia include the Women’s Health Initiative (WHI), the Jackson Heart Study (JHS), MESA, HyperGEN, Generation Scotland, and CATHGEN. In addition, we used kidney DNAm data from the TRANSLATE, TRANSLATE-T, RESPOND, and REPAIR studies for cis-meQTL analyses and Roadmap Epigenomics data for eFORGE DHS analyses