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Table 1 Main characteristics of NBD subtypes

From: Emerging genetic complexity and rare genetic variants in neurodegenerative brain diseases

NBD Brain location Pathology Main symptoms
AD Tempo-parietal lobes β-Amyloid, tau Progressive memory loss, cognitive decline
FTD Frontotemporal lobe TDP43, tau, FUS Behavioral changes, language deficits
PD Midbrain α-Synuclein, Lewy bodies Bradykinesia, muscle rigidity, resting tremor. Dementia features in 30–80%
ALS Motor cortex, spinal cord TDP-43 Muscle weakness, impaired voluntary movements. Dementia features in 50%