Fig. 1

Mutation burden and functional annotations. a Rates of somatic SNVs in IBC and non-IBC cohorts, for all samples, and for ER+ and ER− cases separately. P-values are from Wilcoxon rank sum test. b Number of coding and noncoding somatic SNVs. Each dot represents a sample color-coded by ER status. P-values are from Wilcoxon rank sum test. c Medians of somatic SNVs for various types of coding mutations. d Median numbers of noncoding SNVs by functional class in IBC and non-IBC. Light and dark bars on panels c and d correspond to the numbers for all mutations and deleterious mutations, respectively. Number of mutations in each annotation category was compared between two cohorts by Wilcoxon rank sum test, resulting in p-values ranging from 0.14 to 0.63. Similar tests were implemented for deleterious variants only for each annotation category, with p-values 0.10–0.93. Fractions of deleterious mutations were tested by two-proportions z-test with Yates’ continuity correction, showing all p-values were > 0.05 for each unique annotation category. “NS” in panels c and d represent that all p-values are not significant (p > 0.05)