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Fig. 4 | Genome Medicine

Fig. 4

From: Crosstalk between microRNA expression and DNA methylation drives the hormone-dependent phenotype of breast cancer

Fig. 4

Global methylation alteration (GMA) score in clinical breast cancer groups and correlation to miRNA expression. a, b Boxplots showing the GMA score in estrogen receptor (ER)-positive (pos) and ER-negative (neg) tumors of the Oslo2 (a) and TCGA (b) cohorts. Wilcoxon rank-sum test p values are shown. c, d Boxplots showing the GMA score in PAM50 molecular subtypes of the Oslo2 (c) and TCGA (d) cohorts. LumA: Luminal A, LumB: Luminal B, Basal: Basal-like, Her2: HER2-enriched. Kruskal-Wallis test p values are denoted. e, f Plots showing density curves of the correlation between miRNA cluster members and the GMA score for the Oslo2 (e) and TCGA (f) cohorts. The density lines are color-coded according to miRNA cluster. g, h Barplots showing miRNAs decreasingly ranked according to GMA score correlation level (y-axis) in the Oslo2 (g) and TCGA (h) cohorts. The bars are color-coded according to miRNA cluster

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Genome Medicine

ISSN: 1756-994X

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