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Fig. 5 | Genome Medicine

Fig. 5

From: Whole-genome sequencing with long reads reveals complex structure and origin of structural variation in human genetic variations and somatic mutations in cancer

Fig. 5

Somatic SVs in liver cancers. a Comparison of somatic SVs between short-read study and the current study. Somatic SVs detected by this study were compared with a previous short-read study [2]. b Sensitivity of SV calling in the current study. We calculated the sensitivity for SVs identified by short reads. Variant allele frequencies (VAFs) were estimated from short reads [2]. c Possible mechanism of somatic SVs. The mechanism was estimated as done for germline deletions. The proportions were significantly different between germline deletions and somatic SVs (p value = 9.9 × 10−77, chi-square test). d Comparison of HBV integrations between short-read study and this study. HBV integrations identified by this study were compared with a previous short-read study [2]

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Genome Medicine

ISSN: 1756-994X

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