Skip to main content
Fig. 3 | Genome Medicine

Fig. 3

From: Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH

Fig. 3

Gene expression patterns of PAH risk genes using murine single-cell RNA-seq data. a Heat map showing fraction of cells with > 0 reads in specific cell types of lung, heart, and aorta for 11 known PAH risk genes and 3 new candidate risk genes (KDR, FBLN2, and PDGFD). L, lung; H, heart; A, aorta. b PCA analysis of gene expression for PAH risk genes and a set of 100 randomly selected genes, overlaid on a plot of all other 16,744 sequenced genes expressed in both human and mouse cells. c Histogram of PC2 values for PAH risk genes and a set of 100 randomly selected genes indicates a right shift for PC2 among PAH risk genes. d Relative rank of PC2 values for PAH risk genes among 16,744 sequenced genes expressed in both human and mouse cells.

Back to article page