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Fig. 4 | Genome Medicine

Fig. 4

From: Destination shapes antibiotic resistance gene acquisitions, abundance increases, and diversity changes in Dutch travelers

Fig. 4

Travelers to different destinations cluster separately by resistome composition but show similar trends by abundance and diversity metrics. a The bottom panel shows the comparisons of AMR gene abundance before and after travel to the four subregions in this study. Points correspond to samples, and boxes give the median and interquartile ranges. Pre-travel is shown in blue, and post-travel is shown in red. The p values (FDR-corrected paired Wilcoxon tests) for comparisons within the region between the pre- and post-travel samples are shown above each comparison. The top panel shows the difference between the bootstrapped distributions of the post- and pre-travel samples. The red line gives the 95% confidence interval for the difference, and the point gives the estimate. b AMR gene α-diversity is measured by richness (left), and Shannon Index (right) is compared by region between the pre-travel (blue) and post-travel (red) samples. Each point corresponds to a given sample, and each box gives the median and interquartile range for the distribution. The p values (FDR-corrected paired Wilcoxon test) are above each comparison. The panels above show the difference between the bootstrapped distributions of the post- and pre-travel samples for each destination. The red line gives the 95% confidence interval for the difference, and the point gives the estimate. c The left panel compares the β-diversity for pre-travel (blue) and post-travel (red) collections for the four travel destinations. The points are pairwise Bray-Curtis dissimilarity between two samples, and the boxes represent the median and interquartile ranges of the distributions. p values (paired Wilcoxon test) are given above each comparison. The right panel shows the difference between the bootstrapped dissimilarities of the pre- and post-travel groups. The lines give the 95% confidence interval for the difference, and the point gives the estimate. Source data for all panels is provided in the source data file (Additional file 3)

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