Fig. 1

Study design and sampling dynamics. a Schematic diagram of the analysis workflow from patient selection, sample capture, and sequencing to downstream analyses. We leveraged the Terra Genomics/FireCloud platform for data storage and high-performance computing tasks. b Schematic representation of sampling density for each of the seven cohort members on study, also specifying whether whole exome sequencing and/or targeted panel sequencing was performed on that sample. All samples received ultra-low-pass whole genome sequencing. c Tumor fraction dynamics colored by individual. Tumor fraction was measured on study using ultra-low-pass whole genome sequencing and the ichorCNA algorithm. d Tumor fraction dynamics recolored by RECIST v1.1 response by imaging categories. RECIST v1.1 bucket response type into several categories: complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD)