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Fig. 1 | Genome Medicine

Fig. 1

From: Tumor fraction-guided cell-free DNA profiling in metastatic solid tumor patients

Fig. 1

Estimation of cfDNA tumor fraction by genome-wide copy number profiles or fragment size profiles. a Comparison of shallow whole genome sequencing (sWGS)-estimated z-score distribution between plasma samples from healthy controls and cancer patients with or without mutations detected by cf-IMPACT (cell-free MSK-IMPACT). b Comparison of cfDNA fragment size, expressed as the ratio of the counts between short to long fragments (0–150 bp)/(151–500 bp), in plasma samples from healthy controls and cancer patients with or without mutations detected by cf-IMPACT. c Correlation between sWGS-estimated z-scores and median variant allele fraction (mVAF) as quantitated by cf-IMPACT analysis of plasma cfDNA. Correlation between the ratio of the counts between short to long fragment (0–150 bp)/(151–500 bp) computed from cf-IMPACT data and median variant allele frequency (mVAF) quantitated by cf-IMPACT analysis in cfDNA. d Comparison of model performance of global copy number change (Z-scores) from sWGS and the short to long fragment size ratio computed from cf-IMPACT data to predict high or low tumor fraction

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