Fig. 2

Detection of tumor-derived mutations in plasma by cf-IMPACT as a function of cfDNA tumor fraction. a–c Concordance of mutations detected by tumor and cf-IMPACT as a function of increasing z-scores. Patients with a bladder, b prostate, and c germ cell cancers that had both tumor and plasma mutational data are shown. The top 8% (bladder), 4% (prostate), and 20% (germ cell tumor) most frequently mutated genes are shown. The thresholds of 2.5 and 5 z-scores corresponding to 5% and 10% tumor fraction delineates a clear cutoff between a majority of samples with mutations detected in plasma from samples with few or no plasma mutations detected in each of the cancer types