Fig. 3
From: Tumor fraction-guided cell-free DNA profiling in metastatic solid tumor patients
Agreement between plasma and tumor MSK-IMPACT profiles in the context of sWGS-estimated cfDNA tumor fraction. a Comparison of the proportion of mutations detected in both plasma and tumor (shared, percentages shown on graph), versus mutations detected in tumor only, or plasma only. Data shown for three categories: all samples, samples with low tumor fraction (z-score <5) in plasma, and samples with high tumor fraction (z-score ≥5) in plasma. b Comparison of the proportion of clonal versus subclonal tumor mutation detected in plasma samples. Data shown for three categories: all samples, samples with low tumor fraction (z-score <5) in plasma, and samples with high tumor fraction (z-score ≥5) in plasma. Clonality was defined based on tumor cancer cell fractions estimated by FACETS analysis. c Comparison of mutation burden as quantitated by MSK-IMPACT analysis of tumor and plasma. Samples are color coded based on z-score: ≥5 (blue) versus <5 (gray)