Fig. 3

Cross-phenotype association analysis reveals the same genetic locus impacts both Chlamydia-induced CXCL10 levels and MIG level in serum. a Regional Miami colocalization plot demonstrates a genetic locus that impacts both CXCL10 level in lymphoblastoid cell lines following Chlamydia trachomatis infection and CXCL9 (MIG) levels in serum. b Comparison of -log10(p value) for GWAS of CXCL10 following C. trachomatis infection and levels of CXCL9 (MIG) in serum. The lead SNP in the region for each phenotype is marked. c Scatter plot demonstrates a highly positive correlation of the effect coefficients of cellular CXCL10 after C. trachomatis infection and of SNPs associated with blood CXCL9 levels. Each dot represents a SNP which has p value < 0.01 for both phenotypes. A total of 413 SNPs from a 4-mb window surrounding the leading SNP rs2869462 was selected. The blue vertical or red horizontal bar shows the standard error of the beta value for each SNP