Skip to main content
Fig. 4 | Genome Medicine

Fig. 4

From: An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility

Fig. 4

Cross-phenotype association of ABO reveals a possible role for CD209 in severe COVID-19. a A network of genetic associations involving severe COVID-19. Each node represents either a disease/trait (filled circles) or a gene (dark blue diamond). The ABO locus was associated with multiple other diseases and levels of specific proteins, while DPP9 connects COVID-19 only with IPF and interstitial lung disease (idiopathic interstitial pneumonia). b Regional Miami colocalization plot demonstrates the ABO locus impacts both CD209 protein levels and risk of severe COVID-19. c A significant positive correlation for effect size of SNPs in the ABO locus on CD209 protein levels and risk of severe COVID-19. d Model of how ABO may affect CD209 and severe COVID-19

Back to article page

Genome Medicine

ISSN: 1756-994X

Contact us