Fig. 1

Correlations of chromosome arm-wide gene expression levels and chromosome arm-wide aneuploidies. a Correlation plot of chromosome arm-wide gene expression levels in cancers and patterns of chromosome arm-wide gains and losses in cancers reported in the TCGA database. Bar plot represent the Spearman rank correlations for each cancer type independently. The height of the bar reflects the correlation coefficient, and the size of the circle the significance. Size of 2 indicates p value < 0.01, size of 1 indicates p value < 0.1, and size of 0 indicates p value < 1. b Correlation of chromosome arm-wide gene expression levels based on the GTEx database (left column) with chromosome arm-wide aneuploidies in associated cancer types based on data reported in the TCGA database (right column), respectively, for 19 tissue entities. The arm imbalance score is reflected in colors: red indicates more frequent gains compared to losses; blue indicates more frequent losses compared to gains. The hue of the colors indicates the frequency of copy number changes and the quantile normalized levels of mean chromosome arm-wide gene expression, respectively. Barplots shown beside each heatmap are the Spearman rank correlations (horizontal bars indicate comparisons for each arm independently; vertical bars indicate comparisons for each tissue independently). A size of 2 indicates p value < 0.01, a size of 1 indicates p value < 0.1, and size of 0 indicates p values < 1. TCGA study abbreviations: ACC, adrenocortical carcinoma; BLCA, bladder urothelial carcinoma; BRCA, breast invasive carcinoma; CESC, cervical squamous cell carcinoma and endocervical carcinoma; CHOL, cholangiocarcinoma; COAD, colon adenocarcinoma; DLBC, diffuse large B cell lymphoma; ESCA, esophageal carcinoma; GBM, glioblastoma multiforme; HNSC, head and neck squamous cell carcinoma; KICH, kidney chromophobe; KIRC, kidney renal clear cell carcinoma; KIRP, kidney renal papillary carcinoma; LAML, acute myeloid leukemia; LGG, low-grade glioma; LIHC, liver hepatocellular carcinoma; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; MESO, mesothelioma; OV, ovarian serous cystadenocarcinoma; PAAD, pancreatic adenocarcinoma; PCPG, pheochromocytoma and paraganglioma; PRAD, prostate adenocarcinoma; READ, rectum adenocarcinoma; SARC, sarcoma; SKCM, skin cutaneous melanoma; STAD, stomach adenocarcinoma; TGCT, testicular germ cell tumors; THCA, thyroid carcinoma; THYM, thymoma; UCEC, uterine endometrial carcinoma; UCS, uterine carcinosarcoma; UVM, uveal melanoma