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Fig. 3 | Genome Medicine

Fig. 3

From: Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker

Fig. 3

Single-cell characterization of the pro-tumor features of MARCO+ macrophages. a The mesenchymal signature primarily originates from the macrophage population. b Single-cell expression analysis from paired macrophages and tumor cells from the same samples. The mean MARCO expression within macrophages significantly correlates with mesenchymal subtype score and anti-correlates with proneural subtype score in paired tumor cells. *: p < 0.05; **: p < 0.01; ns: not significant. c MARCO+ macrophages demonstrate an enrichment in gene sets related to the epithelial-mesenchymal transition. d The hypoxia pathway is also enriched in MARCO+ macrophages. e This corroborates with their presence in the tumor core rather than the tumor periphery in 4 pairs of locationally separated samples in Darmanis et al. (black lines in the swarm plots represent means). f Pathways least expressed by MARCO+ macrophages include interferon-alpha response as well as MHC II antigen presentation (g). h Out of all genes surveyed, MARCO expression is distinctly associated with decreased HLA class II gene expression

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