Skip to main content
Fig. 4 | Genome Medicine

Fig. 4

From: scGRNom: a computational pipeline of integrative multi-omics analyses for predicting cell-type disease genes and regulatory networks

Fig. 4

Enrichments of cell-type enhancers and disease genes. a Partitioned heritability enrichment of GWAS SNPs associated with various diseases and traits (bar) on the enhancers of In1a GRN. Bar height is −log10(p value) of the enrichment. The diseases and traits are schizophrenia (SCZ), Alzheimer’s disease (AD), autism spectrum disorder (ASD), bipolar disorder (BPD), amyotrophic lateral sclerosis (ALS), major depressive disorder (MDD), intelligence, multiple sclerosis (MS), Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), education, type 2 diabetes (T2D), inflammatory bowel disease (IBD), and coronary artery disease (CAD). The red line represents p value = 0.05. b The disease enrichments of cell-type AD genes. Rows are diseases/traits. Columns are cell types. Darkness is proportional to −log10(p) of the enriched term. c The disease enrichments of cell-type SCZ genes. Rows are diseases/traits. Columns are cell types. Darkness is proportional to −log10(p) of the enriched term. d The enrichments of functions and pathways (e.g., GO, KEGG, REACOME) in the microglia AD genes. Bar darkness and length are proportional to −log10(p) of the enriched term. e The enrichments of functions and pathways (e.g., GO, KEGG, REACOME) in the excitatory neuronal SCZ genes. Bar darkness and length are proportional to −log10(p) of the enriched term

Back to article page