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Table 1 Data used for the Mendelian randomization analysis. For CAD and T2D participant numbers were split into cases and controls. *Reproducibility of spirometry measurement using ERS/ATS criteria; **European ancestry; ***Stage 1 meta-analysis

From: Genetic correlation and causal relationships between cardio-metabolic traits and lung function impairment

Trait

Source

Year

Imputation panel

N

Trait transformation

FEV1

UKBB & Wain et al. [19]

2017

HRC

270381*

Raw, in liter

FVC

UKBB & Wain et al. [19]

2017

HRC

270381*

Raw, in liter

FEV1/FVC

UKBB & Wain et al. [19]

2017

HRC

270381*

Raw, in liter

BMI

Locke et al. [8]

2015

HapMap2

322154**

Rank inverse normal transformed (BMI~age + age^2 + sex)

T2D

Scott et al. [9]

2017

1kG

26676 (132532)

Case control

CRP

Dehghan et al. [10]

2011

HapMap2

82725

ln(hsCRP)

HDL

Willer et al. [11]

2013

HapMap2

188577

Rank inverse normal transformation (HDL~age+age2+sex)

LDL

Willer et al. [11]

2013

HapMap2

188577

Rank inverse normal transformation (LDL~age+age2+sex)

TC

Willer et al. [11]

2013

HapMap2

188577

Rank inverse normal transformation (TC~age+age2+sex)

TG

Willer et al. [11]

2013

HapMap2

188577

Rank inverse normal transformation (TG~age+age2+sex)

SBP

Wain et al. [12]

2017

1kG

150134***

Residuals of (SBP~sex + age + age^2 + BMI)

DBP

Wain et al. [12]

2017

1kG

150134***

Residulas of (DBP~sex + age + age^2 + BMI)

PP

Wain et al. [12]

2017

1kG

150134***

Residuals of (PP~sex + age + age^2 + BMI)

CAD

Nikpay et al. [13]

2015

1kG

60801 (123504)

Case control