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Table 1 Sample description for WGS cohorts

From: Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program

Population

Cohort

N

Age

Percent female

BMI

Apnea-hypopnea index 3%

AHI (percent < 5, 5–15, ≥ 15)

Average desaturation

Average SpO2

Minimum SpO2

Percent sleep under 90% SpO2

African-American

CFS*

505

38.65 (18.96)

56.4

32.44 (9.48)

6.85 (22.48)

43.4, 20.6, 36.0

3.62 (1.99)

94.49 (3.91)

84.76 (9.83)

4.79 (13.15)

CHS

151

75.39 (4.35)

60.3

29.02 (5.08)

9.60 (16.96)

28.5, 36.4, 35.1

2.70 (1.74)

94.82 (2.19)

85.74 (5.35)

3.39 (9.63)

JHS

575

63.47 (10.94)

64.9

31.8 (6.88)

10.69 (14.42)

24.7, 39.5, 35.8

3.54 (1.72)

94.77 (2.02)

84.30 (6.57)

2.97 (8.91)

MESA

486

68.81 (9.07)

53.7

30.23 (5.68)

12.67 (20.56)

22.4, 32.9, 44.7

3.42 (2.10)

94.46 (1.99)

83.32 (7.98)

3.89 (9.49)

East Asian-American

MESA

229

67.89 (9.11)

49.8

24.28 (3.30)

14.96 (24.28)

21.8, 28.4, 49.8

3.72 (1.79)

94.92 (1.22)

83.23 (7.58)

2.25 (4.46)

European-American

ARIC

1028

62.28 (5.67)

53.1

28.72 (5.06)

8.64 (15.62)

34.6, 32.4, 33.0

2.35 (1.29)

94.57 (1.84)

85.95 (5.93)

2.92 (9.24)

CFS*

485

43.23 (19.49)

50.5

30.81 (8.83)

7.09 (21.90)

44.7, 19.4, 35.9

3.29 (1.86)

93.67 (3.59)

85.55 (9.33)

4.66 (11.87)

CHS

557

77.90 (4.34)

54.2

27.25 (4.44)

11.42 (15.54)

23.2, 38.1, 38.8

2.58 (1.34)

94.00 (2.00)

84.99 (5.67)

4.77 (12.28)

FHS*

478

60.09 (8.54)

49.8

28.40 (5.06)

8.10 (14.28)

35.1, 35.1, 29.7

2.35 (1.27)

94.68 (2.04)

85.78 (6.25)

2.96 (9.18)

MESA

698

68.53 (9.06)

53.2

27.91 (5.10)

12.18 (20.45)

21.6, 35.0, 43.4

3.11 (1.44)

93.96 (1.75)

83.49 (7.50)

4.27 (10.82)

Hispanic/Latino-American

HCHS/SOL

2339

46.27 (13.86)

60.5

30.23 (6.44)

2.03 (6.30)

68.9, 19.5, 11.6

N/A

96.42 (0.99)

87.04 (5.92)

0.88 (3.63)

MESA

456

68.49 (9.27)

53.3

30.08 (5.46)

16.31 (22.53)

17.1, 28.3, 54.6

3.62 (2.12)

94.33 (1.60)

81.59 (9.32)

3.80 (7.64)

  1. Seven studies contributed 7988 individuals with WGS in TOPMed Freeze 6a and objectively measured phenotypes (1717 African-Americans, 229 Asian-Americans, 3246 European-Americans, 2796 Hispanic/Latino-Americans). The overall sample had a mean age of 57.7 and was 56.1% female. Values are displayed as mean (SD), except for the skewed apnea-hypopnea index, which is displayed as median (IQR). Sample size N reflects individuals with non-missing AHI and covariate values. *Family cohort
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