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Table 1 Sample description for WGS cohorts

From: Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program

Population Cohort N Age Percent female BMI Apnea-hypopnea index 3% AHI (percent < 5, 5–15, ≥ 15) Average desaturation Average SpO2 Minimum SpO2 Percent sleep under 90% SpO2
African-American CFS* 505 38.65 (18.96) 56.4 32.44 (9.48) 6.85 (22.48) 43.4, 20.6, 36.0 3.62 (1.99) 94.49 (3.91) 84.76 (9.83) 4.79 (13.15)
CHS 151 75.39 (4.35) 60.3 29.02 (5.08) 9.60 (16.96) 28.5, 36.4, 35.1 2.70 (1.74) 94.82 (2.19) 85.74 (5.35) 3.39 (9.63)
JHS 575 63.47 (10.94) 64.9 31.8 (6.88) 10.69 (14.42) 24.7, 39.5, 35.8 3.54 (1.72) 94.77 (2.02) 84.30 (6.57) 2.97 (8.91)
MESA 486 68.81 (9.07) 53.7 30.23 (5.68) 12.67 (20.56) 22.4, 32.9, 44.7 3.42 (2.10) 94.46 (1.99) 83.32 (7.98) 3.89 (9.49)
East Asian-American MESA 229 67.89 (9.11) 49.8 24.28 (3.30) 14.96 (24.28) 21.8, 28.4, 49.8 3.72 (1.79) 94.92 (1.22) 83.23 (7.58) 2.25 (4.46)
European-American ARIC 1028 62.28 (5.67) 53.1 28.72 (5.06) 8.64 (15.62) 34.6, 32.4, 33.0 2.35 (1.29) 94.57 (1.84) 85.95 (5.93) 2.92 (9.24)
CFS* 485 43.23 (19.49) 50.5 30.81 (8.83) 7.09 (21.90) 44.7, 19.4, 35.9 3.29 (1.86) 93.67 (3.59) 85.55 (9.33) 4.66 (11.87)
CHS 557 77.90 (4.34) 54.2 27.25 (4.44) 11.42 (15.54) 23.2, 38.1, 38.8 2.58 (1.34) 94.00 (2.00) 84.99 (5.67) 4.77 (12.28)
FHS* 478 60.09 (8.54) 49.8 28.40 (5.06) 8.10 (14.28) 35.1, 35.1, 29.7 2.35 (1.27) 94.68 (2.04) 85.78 (6.25) 2.96 (9.18)
MESA 698 68.53 (9.06) 53.2 27.91 (5.10) 12.18 (20.45) 21.6, 35.0, 43.4 3.11 (1.44) 93.96 (1.75) 83.49 (7.50) 4.27 (10.82)
Hispanic/Latino-American HCHS/SOL 2339 46.27 (13.86) 60.5 30.23 (6.44) 2.03 (6.30) 68.9, 19.5, 11.6 N/A 96.42 (0.99) 87.04 (5.92) 0.88 (3.63)
MESA 456 68.49 (9.27) 53.3 30.08 (5.46) 16.31 (22.53) 17.1, 28.3, 54.6 3.62 (2.12) 94.33 (1.60) 81.59 (9.32) 3.80 (7.64)
  1. Seven studies contributed 7988 individuals with WGS in TOPMed Freeze 6a and objectively measured phenotypes (1717 African-Americans, 229 Asian-Americans, 3246 European-Americans, 2796 Hispanic/Latino-Americans). The overall sample had a mean age of 57.7 and was 56.1% female. Values are displayed as mean (SD), except for the skewed apnea-hypopnea index, which is displayed as median (IQR). Sample size N reflects individuals with non-missing AHI and covariate values. *Family cohort