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Table 4 Lead gene-based population-specific results

From: Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program

Phenotype

Model

Gene

B38 positions

N

Variants

Singletons

P

Per90

HA

LINC01277

6:142,985,371–143,010,415

2803

2

0

5.02 × 10−8

 

OR5K2

3:98,497,633–98,498,634

2803

1

0

2.74 × 10−7

AA females

S100A16*

1:153,607,528–153,616,353

1009

1

1

2.07 × 10−7

 

CSMD2-AS1

1:33,867,977–33,885,456

1009

1

1

2.07 × 10−7

EA females

MRPS33

7:141,006,422–141,014,911

1702

9

8

1.22 × 10−9

 

LINC01811

3:34,170,921–34,558,474

1702

6

5

9.71 × 10−8

 

NELFCD*

20:58,980,722–58,995,761

1702

12

10

3.32 × 10−7

 

SLC22A8*

11:62,988,399–63,015,986

1702

3

3

3.58 × 10−7

HA females

AL132709.1

14:101,077,452–101,077,578

1660

2

0

1.41 × 10−7

 

EPHX4

1:92,029,443–92,063,474

1660

12

10

3.48 × 10−7

HA males

C16orf90

16:3,493,483–3,496,479

1143

6

3

1.36 × 10−8

 

TVP23B

17:18,781,270–18,806,714

1143

4

4

2.53 × 10−7

 

IPCEF1

6:154,154,536–154,356,890

1143

10

8

4.07 × 10−7

  1. Lead MMSKAT gene-based population-specific associations within one order of magnitude of significance (p < 4.51 × 10−8) are shown. The Variants column indicates the number of filtered polymorphic variants with minor allele frequency < 5% available for testing, a portion of which were singletons. *Druggable gene [59, 60]. Full results for genes with p < 0.01, including descriptions, are provided in Additional file 1: Table S5. A list of individual variants comprising each gene is provided in Additional file 1: Table S6