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Table 6 Transcription factor binding site interval enrichment results

From: Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program

Phenotype Transcription factor # Observed overlap # Expected overlap −log10 (E-value)
AHI FOXP2 588 36.20 473.99
KDM6B 630 51.58 435.29
THAP1 505 31.89 402.07
KLF9 745 91.81 395.52
TP63 997 182.22 383.85
Average desaturation FOXP2 493 22.32 460.00
THAP1 439 19.55 412.76
UBTF 489 28.20 407.50
TP63 788 109.36 382.89
KDM6B 482 30.98 380.39
Average SpO2 FOXP2 582 35.87 468.89
KDM6B 613 51.21 418.65
EGR1 664 66.76 404.83
UBTF 574 46.35 399.91
KDM4B 489 29.56 398.10
Min SpO2 FOXP2 561 35.57 445.57
THAP1 515 31.32 417.89
KDM6B 569 50.87 373.41
UBTF 536 45.99 360.56
EGR1 602 66.25 346.03
Per90 FOXP2 689 39.05 578.42
KDM6B 739 54.79 539.69
TP63 1199 193.28 515.44
THAP1 607 34.47 509.33
EGR1 786 72.09 507.27
  1. Two-hundred-fifty-base pair sliding window coordinates with association p < 0.01 were queried for interval enrichment of ChIP-seq-derived transcription factor binding sites using the ReMap annotation tool. ChIP-seq coordinates were required to have >50% overlap with a sliding window interval. ReMap-derived expected overlaps are obtained from the equivalent number of similarly sized random regions. E-value indicates the expected value, with a higher log-transformed value indicating greater enrichment. Full results are provided in Additional file 1: Table S14