Fig. 4

Ixabepilone significantly extends survival of mice bearing MYC-amplified Gp3 and SHH PDX. Kaplan-Meier curves representing survival of mice bearing MB PDX following treatment with ixabepilone or vehicle. a Med-211FH brain tumours treated with either ixabepilone (n = 8) or vehicle (n = 7), b Med-411FH brain tumours treated ixabepilone (n = 12) or vehicle (n = 7) and c BT084 brain tumours treated ixabepilone (n = 9) or vehicle (n = 7). Statistical evaluation was performed using the Log-rank (Mantel-Cox) test with statistically significant differences indicated (*P < 0.05)