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Fig. 4 | Genome Medicine

Fig. 4

From: High-grade serous tubo-ovarian cancer refined with single-cell RNA sequencing: specific cell subtypes influence survival and determine molecular subtype classification

Fig. 4

Subclustering of 5950 fibroblasts. A, B t-SNE plots showing the annotated fibroblast subclusters generated by CCA-aligned methods (A), the fraction of fibroblasts originating from either tumour vs non-tumour tissue or from the different sampling sites (ovary, omentum, peritoneum) (B). C t-SNEs with gene expression of either mesothelial cells (IL18, IL6, CCL2, IL6ST), myofibroblasts (ACTA2, PTK2, ITGA8, MEF2C) and cancer-associated fibroblasts expressing EMT-related (COL10A1, COL11A1, MMP11, MMP2) and TGF-β-related genes (COMP, THBS1, SKIL, PDGFC). D, E Heatmap of metabolic activity (D) or TF activity (E) in fibroblast subclusters

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