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Fig. 5 | Genome Medicine

Fig. 5

From: High-grade serous tubo-ovarian cancer refined with single-cell RNA sequencing: specific cell subtypes influence survival and determine molecular subtype classification

Fig. 5

Subclustering of B cells. A, B t-SNE plots showing the annotated B cell subclusters generated by PCA-aligned methods (A), as well as the fraction of B cells originating from each patient, from the different sampling sites (ovary, omentum, peritoneum) and the different types of tissue (normal vs tumour) (B). C Violin plots illustrating the expression of maturity markers (CD38, SDC1, CD27, PRDM1), immunoglobulins (IGHG1, IGHG2, IGHG3, IGHA1) and inflammatory chemokines and receptors (TNFRSF17, CXCR3, CXCL13). D Percentage of cells demonstrating transcription factor activity (regulons) across B cell subclusters (pySCENIC)

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Genome Medicine

ISSN: 1756-994X

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