Fig. 1

Multimorbidities identified in the UKB. a Schematic illustration of how RR is calculated for each pair of diseases. b The distribution of the number of multimorbidities for the UKB diseases. c Multimorbidity tendency of intra- and inter-physiological categories. Color and size of the circles represent the proportions of multimorbidities in all disease pairs within a category or between two categories. The deeper the color and the larger the size of a circle, the higher the proportion is. Star represents adjusted P value < 0.05 (FDR corrected). d The high-confidence multimorbidity network constructed by only including multimorbidities with RR > 15. Each node represents a disease, and each edge represents a multimorbid relationship between two diseases. The color code of a node represents the category of the disease. The size of each node is proportional to the number of its multimorbidities (not restricted to RR > 15)