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Fig. 4 | Genome Medicine

Fig. 4

From: Multi-site tumor sampling highlights molecular intra-tumor heterogeneity in malignant pleural mesothelioma

Fig. 4

Differential infiltration of stromal and immune cell populations. a Unsupervised clustering of the paired tumor samples of eight patients with 209 and 70 tumor samples from the Bueno and TCGA series, respectively, was performed based on cell populations determined by the MCP-counter method. The paired tumor samples of the eight patients (series U1138) are indicated by a color code at the top of the heatmap as well as the series of each tumor sample. b The violin plots show the normalized MCP-counter values of immune and stromal cell populations between paired tumor samples for patients T199LE, T225LE, and T227LE, which are characterized by a hot/cold mixed immune profile. Each cell population is indicated in the box plots by a color point connected by a dotted line between paired tumor samples. The p-values of the Wilcoxon test comparing distribution between paired tumor samples are indicated at the top of the violin plot

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