Skip to main content

Table 1 Codon usage differences between each cancer and its respective normal tissue

From: Distinct signatures of codon and codon pair usage in 32 primary tumor types in the novel database CancerCoCoPUTs for cancer-specific codon usage

Cancer name

Higher in cancer or normal

Codon

% difference

Aggregate transitional cell carcinoma—bladder

Cancer

CGG

5.42

Aggregate transitional cell carcinoma—Bladder

Normal

TGT

5.23

Transitional cell carcinoma—bladder

Cancer

CGG

4.76

Transitional cell carcinoma—bladder

Normal

TGT

5.03

Papillary transitional cell carcinoma—bladder

Cancer

CGG

8.26

Papillary transitional cell carcinoma—bladder

Normal

CCT

9.28

Aggregate carcinoma—breast

Cancer

GGT

15.83

Aggregate carcinoma—breast

Normal

TGT

7.44

Ductal carcinoma—breast

Cancer

GGT

15.06

Ductal carcinoma—breast

Normal

TGT

7.60

Lobular carcinoma—breast

Cancer

GGT

19.60

Lobular carcinoma—breast

Normal

TTA

8.93

Duct and lobular carcinoma—breast

Cancer

GGT

28.12

Duct and lobular carcinoma—breast

Normal

TGT

5.01

Colorectal adenocarcinoma

Cancer

CGT

11.28

Colorectal adenocarcinoma

Normal

TGC

8.23

Left colorectal adenocarcinoma

Cancer

CGT

11.39

Left colorectal adenocarcinoma

Normal

TGC

7.55

Right colorectal adenocarcinoma

Cancer

CGT

12.23

Right colorectal adenocarcinoma

Normal

TGC

10.40

Adenocarcinoma—endometrium

Cancer

GCG

6.06

Adenocarcinoma—endometrium

Normal

CAA

8.52

Endometrioid adenocarcinoma

Cancer

GCG

6.07

Endometrioid adenocarcinoma

Normal

CAA

9.01

Serous cystadenocarcinoma—endometrium

Cancer

GCG

6.86

Serous cystadenocarcinoma—endometrium

Normal

CAA

7.22

Squamous cell carcinoma—head and neck

Cancer

TCC

6.20

Squamous cell carcinoma—head and neck

Normal

CAC

4.78

Squamous cell carcinoma—esophagus

Cancer

CGC

19.16

Squamous cell carcinoma—esophagus

Normal

TAT

22.41

Esophageal adenocarcinoma

Cancer

CGG

17.63

Esophageal adenocarcinoma

Normal

TAT

18.16

Clear cell renal cell carcinoma

Cancer

CGC

6.67

Clear cell renal cell carcinoma

Normal

ATA

6.57

Papillary renal cell carcinoma

Cancer

CGC

11.36

Papillary renal cell carcinoma

Normal

TTA

13.01

Chromophobe renal cell carcinoma

Cancer

CGC

10.11

Chromophobe renal cell carcinoma

Normal

TGC

10.03

Hepatocellular carcinoma

Cancer

CGG

24.19

Hepatocellular carcinoma

Normal

TGT

28.55

Cholangiocarcinoma

Cancer

CGG

47.48

Cholangiocarcinoma

Normal

TGT

61.40

Adenocarcinoma—lung

Cancer

CGT

11.77

Adenocarcinoma—lung

Normal

TGC

13.07

Squamous cell carcinoma—lung

Cancer

CGT

16.52

Squamous cell carcinoma—lung

Normal

TGC

17.95

Adenocarcinoma with mixed subtypes—lung

Cancer

CGT

11.86

Adenocarcinoma with mixed subtypes—lung

Normal

TGT

12.38

Bronchioloalveolar carcinoma

Cancer

TTA

12.15

Bronchioloalveolar carcinoma

Normal

TGC

10.07

Papillary adenocarcinoma—lung

Cancer

CGT

10.82

Papillary adenocarcinoma—lung

Normal

TGT

11.76

Mucinous adenocarcinoma—lung

Cancer

CGG

8.76

Mucinous adenocarcinoma—lung

Normal

CCT

8.90

Prostate adenocarcinoma

Cancer

GGT

3.74

Prostate adenocarcinoma

Normal

ATA

3.57

Adenocarcinoma—stomach

Cancer

TTA

12.74

Adenocarcinoma—stomach

Normal

TGC

5.62

Intestinal type adenocarcinoma—stomach

Cancer

TTA

12.45

Intestinal type adenocarcinoma—stomach

Normal

TGC

5.82

Diffuse type carcinoma—stomach

Cancer

TTA

13.49

Diffuse type carcinoma—stomach

Normal

GTC

5.68

Tubular adenocarcinoma—stomach

Cancer

TTA

13.51

Tubular adenocarcinoma—stomach

Normal

TGC

6.88

  1. This table describes the most pronounced codon usage differences for each cancer type based on median transcriptome-weighted codon usage comparison between each cancer type and its respective normal tissue type. For each cancer type, one codon with higher usage in primary tumor tissue and one codon with higher usage in normal tissue are listed. More codon differences can be found in Additional File 4: Table S3