Fig. 2

Evolution of epiallelic changes during the progression of MM and their clinical impact. a Time to relapse analysis for patients with high (blue, n=9) or low (gray, n = 8) EPM values. b EPM values of NPC samples (NPC eloci, in green) and MM samples at diagnosis (MM eloci in orange). c Correlation between EPM at diagnosis and relapse compared to that in NPCs. d EPM value for each pairwise comparison between diagnosis and relapse (diagnosis vs. relapse eloci). e Selection example of a completely unmethylated methylation pattern, minor at diagnosis, but which becomes predominant at relapse for patient M#20, locus position: chr4: 163266538-163266552. f Proportion of eloci presenting a selection of a methylation pattern at diagnosis compared to NPCs (in gray) and at relapse compared to diagnosis (in blue)