Fig. 3

Methylation disruption in bivalent promoters in MM. Scatterplot of eloci in bivalent promoters as a function of DNA methylation in NPC and diagnosis (a) and at diagnosis and relapse (b) for patient M#17. The color gradient corresponds to the point density (low is green; high is red). c Scatterplot of DNA methylation of the eloci promoters versus RNA expression of the associated genes. d Average methylation epiallele patterns of eloci in promoter CGIs for NPC and diagnosis samples. e Ontological analysis of genes with a bivalent promoter CGI affected by hypermethylated eloci. f Normalized expression values of genes with a promoter CGI containing at least one hypermethylated elocus or no elocus (left) and the variation coefficient of these genes in MM samples (right). g Odds ratios with 95% confidence intervals for the association between gene expression (FPM >1) and promoter methylation (average methylation > 0.75 / average methylation < 0.25) for genes with high (red) or low (blue) PDR levels in the promoter