Fig. 2

PRS scores confirm sexual dimorphism of WHRadjBMI and demonstrate the importance of WHRadjBMI co-expression network genes for WHRadjBMI in males. Plot of the PRS for WHRadjBMI in the testing set of the UK Biobank [27] (n = 261,700) separated for males (dark gray) and females (light gray) as well as for genome-wide PRS (dashed lines) and WHRadjBMI co-expression network PRS (solid lines; i.e., variants within the cis regions of the 347 co-expression network genes (± 500 kb from the ends of the gene)). Odds ratio is calculated based on the proportion of individuals in the top 10th percentile of WHRadjBMI for males and females in each of the 20 quantiles of the PRS separately. Vertical error bars indicate the 95% CI for the odds ratio. Brackets show a fold change (FC) in the odds ratio for the 20th quantile