Fig. 3
From: Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes
TWAS [58] and FOCUS [59] results in GTEx v8 subcutaneous adipose RNA-seq data implicates TBX15 as the only TF in the WHRadjBMI co-expression network causal for WHRadjBMI. A Pairwise Pearson correlation coefficients between all genes in the TBX15 locus (chr1:115476504-121965583) using the normalized gene expression from the GTEx v8 cohort subcutaneous adipose RNA-seq data [41] (n = 581). B Plot of −log10 p value for TWAS association with WHRadjBMI for each gene in the TBX15 locus (chr1:115476504-121965583) with a significant heritability estimate (p < 0.01) in the GTEx v8 cohort genotype and subcutaneous adipose RNA-seq data (n = 581). Size of the point indicates the magnitude of the FOCUS marginal posterior inclusion probability (PIP). Genes included in the final 90% credible set are marked in red. Stars above points indicate a significant TWAS cross-validation p value (p < 0.01)