|
n (%)
|
49 (98.00)
|
100 (100.00)
|
49 (98.00)
|
99 (99.00)
| |
|
Age, years
|
53.28 ± 9.87
|
54.16 ± 9.10
|
53.36 ± 9.49
|
52.73 ± 9.35
|
0.761
|
|
Sex (male), n (%)
|
23 (46.94)
|
59 (59.00)
|
27 (55.10)
|
54 (54.55)
|
0.585
|
|
BW, kg
|
68.37 ± 10.82
|
69.57 ± 9.06
|
69.04 ± 10.48
|
69.58 ± 11.24
|
0.904
|
|
BMI, kg/m2
|
25.05 ± 2.68
|
25.25 ± 2.28
|
25.20 ± 2.69
|
25.02 ± 2.80
|
0.921
|
|
Waist circumference, cm
|
90.08 ± 9.25
|
90.98 ± 7.58
|
91.82 ± 8.13
|
91.13 ± 8.58
|
0.774
|
|
Hip circumference, cm
|
98.17 ± 5.73
|
98.72 ± 7.74
|
98.60 ± 6.20
|
98.10 ± 6.81
|
0.920
|
|
Systolic blood pressure, mmHg
|
120.56 ± 11.88
|
123.08 ± 12.42
|
121.17 ± 13.75
|
122.71 ± 11.37
|
0.591
|
|
Diastolic blood pressure, mmHg
|
77.46 ± 8.94
|
78.57 ± 8.19
|
77.97 ± 7.82
|
76.86 ± 7.68
|
0.516
|
|
Pulse, beats/min
|
73.14 ± 8.29
|
74.15 ± 8.56
|
74.80 ± 7.20
|
74.17 ± 9.18
|
0.812
|
|
ECG
| | | | |
0.225
|
|
Normal, n (%)
|
39 (79.59)
|
64 (64.00)
|
29 (59.18)
|
63 (63.64)
| |
|
Non-clinical significance, n (%)
|
9 (18.37)
|
33 (33.00)
|
17 (34.69)
|
26 (26.26)
| |
|
Clinical significance, n (%)
|
1 (2.04)
|
3 (3.00)
|
3 (6.12)
|
9 (9.09)
| |
|
None, n (%)
|
0 (0.00)
|
0 (0.00)
|
0 (0.00)
|
1 (1.01)
| |
|
FPG, mmol/L
|
6.49 ± 0.64
|
6.40 ± 0.66
|
6.42 ± 0.77
|
6.43 ± 0.71
|
0.881
|
|
30 min post-plasma glucose, mmol/L
|
12.12 ± 1.63
|
11.93 ± 1.84
|
11.76 ± 2.09
|
11.94 ± 1.86
|
0.830
|
|
2-hr PPG, mmol/L
|
11.17 ± 2.41
|
11.40 ± 3.08
|
11.24 ± 2.37
|
11.62 ± 3.08
|
0.906
|
|
HbA1c, %
|
6.19 ± 0.53
|
6.19 ± 0.59
|
6.12 ± 0.72
|
6.23 ± 0.68
|
0.920
|
|
Fasting serum insulin, μIU/mL
|
9.87 (5.91–13.60)
|
10.52 (7.65–13.88)
|
9.56 (7.49–13.89)
|
9.78 (6.69–11.98)
|
0.430
|
|
30 min post-serum insulin, μIU/mL
|
39.16 (21.46–64.74)
|
33.00 (19.75–61.83)
|
34.30 (20.40–51.74)
|
32.98 (23.88–52.84)
|
0.962
|
|
2-hr post-serum insulin, μIU/mL
|
61.85 (40.88–94.43)
|
58.56 (40.50–84.36)
|
69.15 (46.19–88.76)
|
56.26 (36.35–79.12)
|
0.279
|
|
Fasting serum C peptide, ng/mL
|
1.46 (0.60–2.04)
|
1.58 (0.60–2.28)
|
1.38 (0.72–2.13)
|
1.47 (0.63–2.13)
|
0.995
|
|
30 min post-serum C peptide, ng/mL
|
3.29 (2.07–4.44)
|
2.67 (1.52–3.87)
|
2.76 (1.77–3.84)
|
2.79 (1.08–4.53)
|
0.711
|
|
2-hr post-serum C peptide, ng/mL
|
6.01 (3.09–8.92)
|
5.64 (2.16–8.74)
|
6.76 (3.39–8.35)
|
5.82 (2.40–8.32)
|
0.745
|
|
TG, mmol/L
|
2.12 (1.50–2.61)
|
1.71 (1.21–2.46)
|
1.66 (1.03–2.14)
|
1.83 (1.20–2.35)
|
0.253
|
|
TC, mmol/L
|
5.03 ± 1.15
|
4.76 ± 1.01
|
4.44 ± 0.96
|
4.72 ± 0.88
|
0.035
|
|
HDL-C, mmol/L
|
1.15 ± 0.30
|
1.19 ± 0.31
|
1.12 ± 0.27
|
1.15 ± 0.26
|
0.535
|
|
LDL-C, mmol/L
|
3.00 ± 0.88
|
2.85 ± 0.80
|
2.67 ± 0.84
|
2.81 ± 0.79
|
0.260
|
|
HOMA-IR
|
2.69 (1.76–3.41)
|
3.05 (1.88–4.08)
|
2.74 (2.16–3.95)
|
2.75 (1.89–3.45)
|
0.450
|
|
HOMA-β
|
69.66 (42.97–98.37)
|
71.98 (53.23–105.48)
|
68.00 (46.41–96.77)
|
63.53 (48.40–87.79)
|
0.832
|
|
Fasting GLP-1, pmol/L
|
2.38 (1.64–5.24)
|
2.00 (1.53–5.11)
|
2.95 (1.52–5.82)
|
2.71 (1.66–5.99)
|
0.895
|
|
30 min post-GLP-1, pmol/L
|
4.39 (2.71–7.03)
|
4.62 (2.62–7.29)
|
3.77 (2.62–7.28)
|
3.98 (2.37–6.97)
|
0.982
|
|
2-hr post-GLP-1, pmol/L
|
2.31 (1.24–4.34)
|
2.48 (1.80–5.04)
|
3.32 (1.92–5.32)
|
2.48 (1.40–5.04)
|
0.745
|
|
Area under the curve of GLP-1
|
7.48 (4.53–14.40)
|
8.13 (4.91–12.90)
|
6.99 (5.31–13.69)
|
6.95 (4.72–13.34)
|
0.905
|
