Fig. 1
From: Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2
Recombination analysis of betacoronaviruses. a Distribution of 103 inferred recombination events among human and non-human beta-CoV isolates showing the span of each recombinant region along the viral genome with respect to SARS-CoV coordinates. The spike protein and its RBD are highlighted. b Sliding window analysis shows (blue curve) the distribution of recombination breakpoints (either start or end) in 800 nucleotide (nt) length windows upstream (namely, in the 5′ to 3′ direction) of every nt position along the viral genome. The spike protein and in particular the RBD and its immediate downstream region are significantly enriched in recombination breakpoints in betacoronaviruses. Benjamini-Yekutieli (BY) corrected p values are shown (red curve), and the 5% BY FDR is shown for reference (dotted line)