Fig. 6
From: Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2
The effects of specific alleles on RBD binding affinity to hACE2. a Change in the binding energy of SARS-CoV-2 RBD to hACE2 caused by the reverse mutation of each SARS-CoV-2 lineage-specific allele to its ancestral state. Binding energy was assessed by considering each mutation individually as well as all possible combinations among the four different SARS-CoV-2 lineage-specific amino acids. b Binding energy of RaTG13 RBD to hACE2 after mutating positions 427 and 436 (either individually or both together) to the SARS-CoV/SARS-CoV-2 alleles