Skip to main content
Fig. 6 | Genome Medicine

Fig. 6

From: Transfer learning between preclinical models and human tumors identifies a conserved NK cell activation signature in anti-CTLA-4 responsive tumors

Fig. 6

NK cell activation regulates CTLA-4 expression. A Effect of 24-h stimulation with IL-2, IL-12, IL-15, and IL-18 on NK cell CTLA-4 expression as determined by qRT-PCR (n = 3 for NK cell lines, 2 for donor NK cells; p-values < 0.01 = ** and < 0.0001 = **** when comparing ΔCt for that cell after exposure to cytokine to that cell line unexposed using an unpaired two-tailed t-test). B Effect of target cell exposure (K562-4-1BB-mbIL-21) on NK cell CTLA-4 expression as determined by qRT-PCR (n = 3, p-value < 0.0001 = **** when comparing ΔCt using an unpaired two-tailed t-test)

Back to article page

Genome Medicine

ISSN: 1756-994X

Contact us