Fig. 7

Preclinical NK activation signature is associated with overall survival in human melanoma. A Coefficients of an age-adjusted multivariate Cox proportional hazards regression model that relates CoGAPS patterns and overall survival in metastatic melanoma lesions from TCGA. Point size scaled to the coefficient’s p-value. Red points indicate patterns with significant coefficients. A positive coefficient indicates a worse overall survival and a negative coefficient indicates a better prognosis for the associated variable. B Coefficients of an age-adjusted multivariate Cox proportional hazards regression model that relates CoGAPS pattern 7 and overall survival across 32 primary tumor types from TCGA. Point size scaled to the coefficient’s p-value. Red points indicate patterns with significant coefficients. C Boxplot of CIBERSORT scores estimating the abundance of resting and activated NK cells from TCGA RNA-seq data by tumor subtype in TCGA. D Bar plot of Spearman correlation coefficients between CTLA-4 and CIBERSORT cell type score for immunogenic cancers. CTLA-4 expression is positively correlated with estimation of activated NK cells from TCGA RNA-seq data. Significant correlations for NK scores and CTLA-4 expression are indicated by asterisks where p-values < 0.05 = *, < 0.01 = **, and < 0.001 = ***