Fig. 3

Differential DNA methylation in skin cell subtypes and cancer cells of origin. A MCC-specific DNA methylation (Fig. 1A) was compared to DNA methylation data from epidermis, dermis, tibial neuron, and epilepsy brain tissues. B PCA plot showing MCC was well separated from dermis, epidermis, tibial neuron, and epilepsy brain tissues. C Unsupervised clustering the MCC-specific DNA methylation profiles (Fig. 1A) with DNA methylation data from SCLC tissues, SCLC cell lines, MCC cell lines (MS1 and MCC13), lung carcinoids, pancreatic tumors, prostate tumors, and pediatric high-grade gliomas (pHGG). D PCA plot of Normal tissue, primary MCC tumors, with SCLC, SCLC cell lines, MCC cell lines (MS1 and MCC13), lung carcinoids, pancreatic tumors, prostate tumors, and pediatric high-grade gliomas (pHGG)