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Fig. 6 | Genome Medicine

Fig. 6

From: Developmental dynamics of voltage-gated sodium channel isoform expression in the human and mouse brain

Fig. 6

Identification of protein-coding exons with complex developmental trajectories. A The correlation between the ratio of CPM expression between pairs of exons (log-scaled) and developmental stage (post-conceptual days, log-scaled) for SCN1A was assessed with a linear model (e.g., Fig. 2B). The R2 value of each exon pair is shown as a heat map with ‘hot’ colors representing exon pairs with high R2 values for which variation in the ratio is correlated with developmental age, i.e., pairs of exons that show substantially different expression across development. Exon numbers from DEXSeq (Additional file 3: Table S2) are shown on the bottom and right and equivalent CDS numbers are shown on the top and left (see Additional file 3: Table S2). BD The analysis is repeated for SCN2A, SCN3A, and SCN8A

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