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Table 1 Clinical diagnosis, symptoms, and information of subjects. Within the new prospective cohort, patients with tissue metaplasia (MET) were older than patients with normal esophagi (P = 0.032—ANOVA post hoc Tukey’s test). While mean BMI increased with the progression of the cascade, no significant differences were observed (ANOVA post hoc Tukey’s test). As the researchers were blinded to clinical diagnosis until after sequencing, one patient found to have squamous cell carcinoma was excluded from further analyses. Within the published cohort, no significant differences in age were identified across groups (F2,97 = 1.19, P = 0.31; ANOVA). Patient BMI was not available. NORM normal, GERD gastro-esophageal reflux disease, MET metaplasia, M male, Y yes, PPI proton pump inhibitor, BMI body mass index. Age and BMI ± standard error of the mean

From: Multi-omics of the esophageal microenvironment identifies signatures associated with progression of Barrett’s esophagus

Cohort Disease Number (%) Age (years) Gender (M) BMI Reflux symptoms (Y) PPI (Y)
Prospective NORM 27 (57.4) 51.2 ± 3.1 7 25.4 ± 0.7 8 13
  GERD 13 (27.6) 57.3 ± 4.9 5 26.3 ± 1.2 6 6
  MET 7 (14.9) 68.8 ± 4.0 4 28.6 ± 1.5 2 4
Published NORM 59 (59.0) 53.1 ± 1.9 21 1 32
  GERD 29 (29.0) 52.0 ± 2.5 8 28 9
  MET 12 (12.0) 59.2 ± 3.6 10 9 9