Fig. 2

Mutations in cancer-critical genes are more frequently expressed. a The gene-wise proportion of mutated loci with mutant allele expression (calculated relative to all tumors in the in-house series with non-synonymous SNVs, frameshift indels, or splice site mutations in each gene) is plotted on the vertical axis, and the mutation frequency on the horizontal axis. Selected genes are indicated with names and colored according to the labels defined in e. b Density plot of the proportion of mutations with expression of the mutated allele, grouped according to target gene category (oncogenes/tumor suppressor genes were defined by the Cancer Gene Census (CGC)). c Density plot of DNA MAFs grouped according to target gene category and plotted separately for expressed and non-expressed mutations, as well as for mutations at copy number balanced loci only. d Density plot of the proportion of mutations at copy number balanced loci with the expression of the mutated allele, grouped according to target gene category. e Frequency plot of the 27 genes with expressed mutations in more than 5% of the tumors, plotted in decreasing order