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Fig. 4 | Genome Medicine

Fig. 4

From: The expressed mutational landscape of microsatellite stable colorectal cancers

Fig. 4

TP53 and RAS mutant allele expression levels correlate with downstream oncogenic signatures. a Scatter plot (top left) of RNA-level versus DNA-level MAFs in TP53. The skewedness of mutant allele-specific expression levels according to mutation type and DNA copy numbers at the mutated loci with allelic imbalance is summarized in the density plot (top right panel) and shown to correspond to the gene expression level of TP53 (left bottom panel). The scatter plot in the right bottom panel shows the normalized allele-specific read counts of TP53 mutations compared to a sample-wise gene expression signature of wild-type TP53. The correlation is indicated for missense SNVs, while the expression levels of truncating mutations were too low for accurate analyses. b Density plot (top) of the difference between the RNA-level and the DNA-level MAFs in KRAS and NRAS (RAS) grouped according to the DNA copy number at the mutated loci (imbalanced loci with total copy number 1 or above 4 were not included in the density plot due to small group sizes). Scatter plot (bottom left) shows RNA MAFs of KRAS mutations (color-coded according to target codon) compared to a sample-wise gene expression signature of mutant KRAS. The Kaplan-Meier plot shows the 5-year overall survival in patients with BRAF wild-type stage II and III CRC, grouped according to RAS mutation status (wt, wild-type) and RNA MAFadjusted of the missense SNVs

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