Fig. 3
Molecular characteristics of the de novo LMS framework. a GSEA of selected gene expression signatures shows distinct patterns of activated (red) or downregulated (blue) pathways. The color intensities represent p values from comparison of each subtype against all others (analyzing one randomly selected CRLM sample from each patient, n = 169). b From top: TP53/KRAS/NRAS/BRAFV600E mutation frequency across patients, with and without subtype stratification (for the latter, calculated per subtype). Bottom: Frequency of RAS/TP53 co-mutations in each subtype