Skip to main content
Fig. 7 | Genome Medicine

Fig. 7

From: Profiling diverse sequence tandem repeats in colorectal cancer reveals co-occurrence of microsatellite and chromosomal instability involving Chromosome 8

Fig. 7

Inter-chromosomal rearrangement in a CRC tumor with a mixed MSI/CIN phenotype. a Haplotypes of chromosome 8 in the normal and tumor samples of P1505. The blocks indicate the original haplotype blocks determined by linked read sequencing, and their color denotes their parental assignment. Haplotype 1 (blue) in the tumor sample displays an allelic imbalance on chromosome 8q that reflects a duplication event, beginning at the translocation breakpoint with chromosome 15. The density plots to the right reflect the distribution of the haplotype counts. b The translocation event from the tumor sample of P1505 (an MSI/CIN-L tumor). For the CIRCOS plot (right), an inter-chromosomal change is indicated with an orange line. Chromosomes are indicated as curved boxes along the circle, with chromosome 1 at the 12 o’clock position, and continuing in a clockwise direction. The width of the box represents the size of the chromosome. Inside the boxes, the log2 copy number ratio from genomic segments is displayed as a heatmap, where orange and blue colors indicate copy number gain and loss, respectively. The left panels show molecular barcodes from linked read sequences that are found in two genomic regions flanking the breakpoints of the translocation. Each row indicates individual DNA molecules. The alignment of barcoded reads is indicated by horizontal lines located at the genomic positions (x-axis)

Back to article page