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Table 1 Frequency of allele shifts in traditional MSI markers

From: Profiling diverse sequence tandem repeats in colorectal cancer reveals co-occurrence of microsatellite and chromosomal instability involving Chromosome 8

   

All shifts

≥3bp shifts

STR ID

Panel

Motif

Frequency in MSI (N = 9)

Frequency in MSS (N = 37)

Accuracy

Frequency in MSI (N = 9)

Frequency in MSS (N = 37)

Accuracy

NR-21

Powerplex

A

100%

0%

100%

100%

0%

100%

BAT26

Bethesda, Powerplex

A

100%

19%

84%

100%

0%

100%

BAT25

Bethesda, Powerplex

T

100%

28%

76%

100%

0%

100%

D17S250

Bethesda

GT

100%

29%

74%

67%

0%

97%

D5S346

Bethesda

TG

78%

0%

96%

22%

0%

85%

D2S123

Bethesda

CA

67%

0%

93%

56%

0%

91%

MSI-H with all Bethesda markersa

100%

19%

85%

100%

0%

100%

  1. aTwo or more shifts among five markers determine MSI-H