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Table 1 Thirty-five genes that have not been previously identified in TWAS for AD risk

From: A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes

Region

Gene name

Typea

Combined P value

Index SNP(s)b

Distance of gene to the index SNP (kb)

1q23.3

NDUFS2

Protein

2.81 × 10−10

rs4575098

11.50

 

FCER1G

Protein

7.43 × 10−10

rs4575098

29.63

 

B4GALT3

Protein

1.45 × 10−6

rs4575098

7.63

 

NIT1

Protein

1.85 × 10−6

rs4575098

60.16

4q25

FAM241A

Protein

2.88 × 10−6

rs6448451

102,041.93

6p12.3

AL355353.1

lncRNA

3.16 × 10−8

rs9381563

12.34

 

CD2AP

Protein

1.98 × 10−7

rs10948363

Within

6p21.32

BTNL2

Protein

1.95 × 10−11

rs9271192

203.63

6p21.33

SAPCD1

Protein

3.61 × 10−8

rs9271192

845.90

7q22.1

PVRIG

Protein

4.44 × 10−9

rs7384878

112.94

 

AZGP1

Protein

3.96 × 10−8

rs7384878

358.38

 

AC004522.3

lncRNA

5.00 × 10−8

rs7384878

385.81

 

CNPY4

Protein

1.85 × 10−7

rs7384878

208.92

 

CASTOR3

Protein

2.77 × 10−7

rs7384878

62.19

 

LAMTOR4

Protein

3.35 × 10−7

rs7384878

178.48

 

STAG3

Protein

5.62 × 10−7

rs7384878

112.94

 

GJC3

Protein

8.58 × 10−7

rs7384878

404.81

 

GPC2

Protein

2.31 × 10−6

rs7384878

157.05

 

AP4M1

Protein

2.78 × 10−6

rs7384878

224.08

11q12.1

FAM111A

Protein

9.60 × 10−7

rs983392

1001.00

15q21.3

AC090515.2

lncRNA

1.13 × 10−6

rs442495

37.66

15q21.3-q22.1

MINDY2

Protein

1.43 × 10−6

rs442495

40.78

16p11.2

KAT8

Protein

9.70 × 10−10

rs59735493

Within

 

PRSS36

Protein

2.96 × 10−9

rs59735493

17.15

 

AC135050.6

lncRNA

9.24 × 10−8

rs59735493

Within

 

PRSS53

Protein

2.25 × 10−7

rs59735493

32.15

 

ZNF668

Protein

1.81 × 10−6

rs59735493

47.54

 

CCDC189

Protein

2.16 × 10−6

rs59735493

359.56

 

AC135050.1

lncRNA

2.66 × 10−6

rs59735493

58.98

17p13.2

AC012146.1

lncRNA

8.33 × 10−8

rs9916042

30.32

 

SCIMP

Protein

1.47 × 10−6

rs9916042

127.77

17q23.3

ACE

Protein

8.67 × 10−8

rs28394864

14,103.65

19q13.31-13.32

AC243964.3

lncRNA

5.89 × 10−25

rs75627662

185.10

19q13.32

GEMIN7

Protein

5.79 × 10−7

rs75627662

168.88

 

OPA3

Protein

1.12 × 10−6

rs76320948

136.37

  1. aProtein: protein coding genes; lncRNA: long noncoding RNAs; bThe risk SNP closest to the gene is presented and a full list of all risk SNPs, and their distances to the genes are presented in Additional file 6: Table S6
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Genome Medicine

ISSN: 1756-994X

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