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Table 1 Thirty-five genes that have not been previously identified in TWAS for AD risk

From: A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes

Region Gene name Typea Combined P value Index SNP(s)b Distance of gene to the index SNP (kb)
1q23.3 NDUFS2 Protein 2.81 × 10−10 rs4575098 11.50
  FCER1G Protein 7.43 × 10−10 rs4575098 29.63
  B4GALT3 Protein 1.45 × 10−6 rs4575098 7.63
  NIT1 Protein 1.85 × 10−6 rs4575098 60.16
4q25 FAM241A Protein 2.88 × 10−6 rs6448451 102,041.93
6p12.3 AL355353.1 lncRNA 3.16 × 10−8 rs9381563 12.34
  CD2AP Protein 1.98 × 10−7 rs10948363 Within
6p21.32 BTNL2 Protein 1.95 × 10−11 rs9271192 203.63
6p21.33 SAPCD1 Protein 3.61 × 10−8 rs9271192 845.90
7q22.1 PVRIG Protein 4.44 × 10−9 rs7384878 112.94
  AZGP1 Protein 3.96 × 10−8 rs7384878 358.38
  AC004522.3 lncRNA 5.00 × 10−8 rs7384878 385.81
  CNPY4 Protein 1.85 × 10−7 rs7384878 208.92
  CASTOR3 Protein 2.77 × 10−7 rs7384878 62.19
  LAMTOR4 Protein 3.35 × 10−7 rs7384878 178.48
  STAG3 Protein 5.62 × 10−7 rs7384878 112.94
  GJC3 Protein 8.58 × 10−7 rs7384878 404.81
  GPC2 Protein 2.31 × 10−6 rs7384878 157.05
  AP4M1 Protein 2.78 × 10−6 rs7384878 224.08
11q12.1 FAM111A Protein 9.60 × 10−7 rs983392 1001.00
15q21.3 AC090515.2 lncRNA 1.13 × 10−6 rs442495 37.66
15q21.3-q22.1 MINDY2 Protein 1.43 × 10−6 rs442495 40.78
16p11.2 KAT8 Protein 9.70 × 10−10 rs59735493 Within
  PRSS36 Protein 2.96 × 10−9 rs59735493 17.15
  AC135050.6 lncRNA 9.24 × 10−8 rs59735493 Within
  PRSS53 Protein 2.25 × 10−7 rs59735493 32.15
  ZNF668 Protein 1.81 × 10−6 rs59735493 47.54
  CCDC189 Protein 2.16 × 10−6 rs59735493 359.56
  AC135050.1 lncRNA 2.66 × 10−6 rs59735493 58.98
17p13.2 AC012146.1 lncRNA 8.33 × 10−8 rs9916042 30.32
  SCIMP Protein 1.47 × 10−6 rs9916042 127.77
17q23.3 ACE Protein 8.67 × 10−8 rs28394864 14,103.65
19q13.31-13.32 AC243964.3 lncRNA 5.89 × 10−25 rs75627662 185.10
19q13.32 GEMIN7 Protein 5.79 × 10−7 rs75627662 168.88
  OPA3 Protein 1.12 × 10−6 rs76320948 136.37
  1. aProtein: protein coding genes; lncRNA: long noncoding RNAs; bThe risk SNP closest to the gene is presented and a full list of all risk SNPs, and their distances to the genes are presented in Additional file 6: Table S6