Table 2 Fine-mapping results based on TWAS-identified genes for AD risk

1q23.3

NDUFS2

161166894

161184185

Brain caudate basal ganglia

0.96 (0.95–0.97)

1.83 × 10⁻⁹

0.96

Brain anterior cingulate cortex BA24

0.95 (0.93–0.96)

6.79 × 10⁻¹⁰

1

Brain hippocampus

0.94 (0.92–0.96)

3.29 × 10⁻¹⁰

1

FCER1G

161185024

161190489

Brain hypothalamus

0.92 (0.89–0.94)

1.44 × 10⁻⁹

0.97

1q32.2

CR1

207669492

207813992

Brain hypothalamus

1.20 (1.15–1.25)

1.00 × 10⁻¹⁶

1

Brain nucleus accumbens basal ganglia

1.17 (1.13–1.21)

1.44 × 10⁻¹⁷

1

Brain anterior cingulate cortex BA24

1.13 (1.10–1.16)

2.47 × 10⁻¹⁷

1

Brain caudate basal ganglia

1.13 (1.10–1.16)

1.22 × 10⁻¹⁷

1

Brain hippocampus

1.12 (1.09–1.15)

6.76 × 10⁻¹⁷

1

Brain amygdala

1.12 (1.09–1.15)

2.60 × 10⁻¹⁷

1

Brain substantia nigra

1.12 (1.09–1.15)

2.28 × 10⁻¹⁷

1

Brain cortex

1.11 (1.09–1.14)

7.96 × 10⁻¹⁸

1

Brain putamen basal ganglia

1.11 (1.09–1.14)

1.41 × 10⁻¹⁷

1

6p21.32

BTNL2

32361740

32374905

Brain caudate basal ganglia

1.07 (1.05–1.10)

5.09 × 10⁻¹²

1

Brain cortex

1.05 (1.03–1.07)

1.10 × 10⁻⁶

0.91

7q22.1

AC004522.3

99527015

99546243

Brain amygdala

0.96 (0.94–0.97)

2.63 × 10⁻⁸

0.93

GPC2

99767229

99774995

Brain putamen basal ganglia

1.04 (1.02–1.05)

1.71 × 10⁻⁶

0.96

PVRIG

99815864

99819113

Brain hippocampus

0.98 (0.97–0.99)

9.74 × 10⁻⁹

0.93

NYAP1

100081550

100092422

Brain hypothalamus

0.86 (0.82–0.91)

2.72 × 10⁻⁹

1

8p21.1

CLU

27454434

27472548

Brain putamen basal ganglia

0.92 (0.90–0.94)

3.77 × 10⁻¹³

1

16p11.2

KAT8

31127075

31142714

Pituitary

0.98 (0.97–0.99)

1.28 × 10⁻⁹

0.98

Brain hippocampus

0.98 (0.97–0.98)

4.90 × 10⁻¹⁰

0.96

Brain caudate basal ganglia

0.98 (0.97–0.98)

1.43 × 10⁻⁹

0.93

Brain amygdala

0.98 (0.97–0.98)

1.16 × 10⁻⁹

0.93

Brain substantia nigra

0.97 (0.97–0.98)

1.64 × 10⁻⁹

1

Brain anterior cingulate cortex BA24

0.97 (0.96–0.98)

3.59 × 10⁻¹⁰

0.98

17p13.2

AC012146.1

5014763

5017674

Brain caudate basal ganglia

0.97 (0.97–0.98)

5.29 × 10⁻⁸

0.96

Brain hippocampus

0.97 (0.97–0.98)

1.98 × 10⁻⁷

0.96

Brain amygdala

0.97 (0.96–0.98)

4.12 × 10⁻⁸

0.97

17q23.3

ACE

61554422

61599205

Brain anterior cingulate cortex BA24

0.97 (0.96–0.98)

5.18 × 10⁻⁸

0.99

19q13.31-13.32

AC243964.3

45135500

45222031

Brain amygdala

1.04 (1.03–1.05)

1.78 × 10⁻²⁵

1

Brain anterior cingulate cortex BA24

1.03 (1.03–1.04)

6.17 × 10⁻²⁵

1

Brain putamen basal ganglia

1.03 (1.02–1.03)

8.54 × 10⁻²⁵

1

Pituitary

1.03 (1.02–1.03)

1.17 × 10⁻²⁴

1

19q13.31

CEACAM19

45165545

45187631

Brain amygdala

1.05 (1.04–1.06)

5.36 × 10⁻²⁰

1

Brain anterior cingulate cortex BA24

1.04 (1.03–1.05)

1.66 × 10⁻¹⁵

0.99

19q13.32

NECTIN2

45349432

45392485

Brain substantia nigra

0.92 (0.90–0.93)

2.67 × 10⁻²⁷

1

Pituitary

0.98 (0.96–0.99)

4.62 × 10⁻³

1

TOMM40

45393826

45406946

Pituitary

9.05 (8.19–9.99)

0

1

APOE

45409011

45412650

Brain substantia nigra

1.42 (1.38–1.46)

7.92 × 10⁻¹³⁵

1

Pituitary

0.86 (0.84–0.89)

4.89 × 10⁻²⁴

1

APOC4

45445495

45452820

Brain putamen basal ganglia

0.98 (0.98–0.99)

2.65 × 10⁻¹²

1

APOC2

45449243

45452822

Brain anterior cingulate cortex BA24

1.08 (1.06–1.11)

7.84 × 10⁻¹²

1

Brain putamen basal ganglia

1.03 (1.02–1.04)

2.77 × 10⁻⁸

1

Pituitary

0.95 (0.93–0.97)

1.33 × 10⁻⁵

1

ZNF296

45574758

45579846

Brain amygdala

0.89 (0.86–0.92)

2.90 × 10⁻¹²

1

KLC3

45836692

45854778

Brain amygdala

0.94 (0.92–0.97)

1.49 × 10⁻⁶

0.94