Fig. 3
From: Single-cell exome sequencing reveals multiple subclones in metastatic colorectal carcinoma
Overview of scWES data. A Boxplot shows the single-cell somatic SNV burdens of the primary tumour (blue), metastatic tumour (red), and normal colon tissue (green). B Barplots show the percentage of bulk-specific SNVs (blue), single-cell-specific SNVs (red), and common SNVs (green) between matched single-cell and bulk tumour samples of CRC4 and CRC7. C Dot plots show the correlation between SNV frequency in single cells (x-axis) and SNV mutation allele frequency in matched bulk samples (y-axis). The SNVs with low mutation allele frequencies defined in Additional file 2: Fig S2B are coloured blue (low-MAF SNVs). Common SNVs defined in both bulk and single cells are coloured green (common SNVs)