Fig. 5
From: Single-cell exome sequencing reveals multiple subclones in metastatic colorectal carcinoma
Cell lineage tree and subclone mutation profile of mCRCs. A, B Phylogenetic tree on the left panel shows single cells from CRC4 (A) and CRC7 (B). Cells are colour-coded based on the sampling location. The heatmap in the right panel shows the mutation profile of each cell in the phylogenetic tree. Gene mutations frequently occurring in primary and metastatic tumour cell clones are framed in blue and red, respectively. Mutations shared by most tumour cells are framed in black, and CRC-associated genes are labelled in red