Fig. 2

Prevalence of affected genes across ancestries. A Frequency/count of NC P/LP carriers in each ancestry among the ACMG 59 genes and the top 10% genes (ranked by sums of all defined ancestry frequencies, excluding Mix and Other). The ACMG genes affected were shown at the upper panel while the top 10% genes at the lower panel. The genes associated with autosomal-dominantly inherited diseases were labeled red. B Variant count of predisposing variants in the matched gnomAD ancestry (European of gnomAD is the union of FIN and NFE populations). TCGA population-specific NC P/LPs, exclusively found in a specific TCGA ancestry, are shown as a triangle. Top NC P/LP or top TCGA ancestry-specific NC P/LP, ranked by allele counts in TCGA or gnomAD, was labeled