Table 1 Enrichment estimates of airway epithelial cell eQTLs and meQTLs for GWAS SNPs. P values and diseases that are significant after FDR correction (see the “Methods” section) are shown in bolded type (FDR < 0.05)
GWAS | NCases | NControls | NTotal | GWAS threshold | OR | P | FDR | |
|---|---|---|---|---|---|---|---|---|
Non-allergic disease GWAS | Alzheimer’s disease [45] | 47,793 | 328,320 | 376,311 | 1.0 × 10−5 | 0.68 | 2.3 × 10−1 | 2.6 × 10−1 |
1.0 × 10−6 | 0.60 | 2.2 × 10−1 | 2.6 × 10−1 | |||||
1.0 × 10−7 | 0.64 | 3.5 × 10−1 | 3.7 × 10−1 | |||||
1.0 × 10−8 | 0.46 | 1.9 × 10−1 | 2.4 × 10−1 | |||||
Atrial fibrillation [46] | 60,620 | 970,216 | 1,030,836 | 1.0 × 10−5 | 1.19 | 3.6 × 10−1 | 3.7 × 10−1 | |
1.0 × 10−6 | 1.17 | 5.2 × 10−1 | 5.2 × 10−1 | |||||
1.0 × 10−7 | 1.41 | 2.3 × 10−1 | 2.6 × 10−1 | |||||
1.0 × 10−8 | 1.70 | 1.3 × 10−1 | 1.7 × 10−1 | |||||
Height [47] | NA | NA | 253,288 | 1.0 × 10−5 | 1.23 | 2.5 × 10−1 | 2.7 × 10−1 | |
1.0 × 10−6 | 1.38 | 1.4 × 10−1 | 1.9 × 10−1 | |||||
1.0 × 10−7 | 1.50 | 1.2 × 10−1 | 1.7 × 10−1 | |||||
1.0 × 10−8 | 1.51 | 1.6 × 10−1 | 2.0 × 10−1 | |||||
Neuroticism [48] | 130,664 | 330,470 | 461,134 | 1.0 × 10−5 | 1.50 | 3.6 × 10−2 | 5.4 × 10−2 | |
1.0 × 10−6 | 1.98 | 1.0 × 10−2 | 1.6 × 10−2 | |||||
1.0 × 10−7 | 3.53 | 2.0 × 10−3 | 3.9 × 10−3 | |||||
1.0 × 10−8 | 8.64 | 9.3 × 10−4 | 1.9 × 10−3 | |||||
Allergic disease GWAS | Allergic rhinitis [71] (multi-ethnic) | 26,910 | 83,424 | 110,334 | 1.0 × 10−5 | 4.82 | 1.6 × 10−5 | 9.3 × 10−5 |
1.0 × 10−6 | 7.32 | 5.5 × 10−5 | 2.5 × 10−4 | |||||
1.0 × 10−7 | 5.39 | 3.2 × 10−3 | 5.5 × 10−3 | |||||
1.0 × 10−8 | 9.63 | 2.4 × 10−3 | 4.3 × 10−3 | |||||
Atopic dermatitis [72] | 11,025 | 40,398 | 51,423 | 1.0 × 10−5 | 3.86 | 7.5 × 10−4 | 7.4 × 10−4 | |
1.0 × 10−6 | 4.54 | 5.5 × 10−3 | 2.0 × 10−4 | |||||
1.0 × 10−7 | 6.35 | 5.5 × 10−3 | 3.4 × 10−4 | |||||
1.0 × 10−8 | 7.96 | 1.7 × 10−2 | 3.1 × 10−5 | |||||
Asthma GWAS | Asthma [10] (multi-ethnic; all ages of onset) | 23,948 | 118,538 | 142,486 | 1.0 × 10−5 | 4.64 | 1.3 × 10−4 | 3.8 × 10−4 |
1.0 × 10−6 | 6.95 | 1.7 × 10−4 | 3.8 × 10−4 | |||||
1.0 × 10−7 | 6.44 | 2.1 × 10−3 | 3.9 × 10−3 | |||||
1.0 × 10−8 | 5.16 | 8.9 × 10−3 | 1.5 × 10−2 | |||||
Adult onset asthma [1] | 21,564 | 318,237 | 339,801 | 1.0 × 10−5 | 7.14 | 8.9 × 10−7 | 1.6 × 10−5 | |
1.0 × 10−6 | 8.06 | 1.4 × 10−4 | 3.9 × 10−4 | |||||
1.0 × 10−7 | 11.7 | 3.9 × 10−4 | 8.7 × 10−4 | |||||
1.0 × 10−8 | 31.8 | 1.8 × 10−4 | 4.7 × 10−4 | |||||
Childhood onset asthma [1] | 9,433 | 318,237 | 327,670 | 1.0 × 10−5 | 2.83 | 3.5 × 10−6 | 3.1 × 10−5 | |
1.0 × 10−6 | 4.63 | 1.1 × 10−7 | 4.1 × 10−6 | |||||
1.0 × 10−7 | 4.77 | 4.4 × 10−6 | 3.1 × 10−5 | |||||
1.0 × 10−8 | 4.36 | 9.2 × 10−5 | 3.4 × 10−4 |